18 October, 2011

08 October, 2011

Y Chromosome analysis is not useful..........

During Y-STR analyses, genetic abnormalities—such as duplications or deletions—can complicate data interpretation. It is important to keep in mind the possibility of rearrangements involving Y-STRs used in forensic investigations, especially when more than one peak is present in a Y single-copy locus. In fact these alterations could address to a wrong mixed (originated from two or more individuals) DNA profile interpretation. In a routine paternity testing, it was found that a father/son pair with double peaks at two loci. Both these markers are included in a commercially available kit used in forensic genetics. One locus is also included in  SWGDAM-recommended Y-STR panel. Moreover, since both these markers map in AZFa region, samples were analyzed to clarify a possible relationship between this Y-STR profile and infertility. For the same reason, two half-brothers involved in a deficiency paternity testing with null allele at DYS448  locus, were analyzed for AZFc region deletions. Since DYS448 null types were already described, these samples were compared with the literature data. A null Y-STR locus should not
represent a problemfor profile interpretation,more than one peak at one or more loci could lead up to a  deep misinterpreting of a profile and therefore from which kind of sample the profile come out

05 October, 2011

Statistical Error Leads to Genetics Retraction

This is the level to which scientific data is being published without verification. Wonder how it came to be peer reviewed and recommended for publication.

BioTechniques - Statistical Error Leads to Genetics Retraction